pentobarbital will minimize the level or outcome of acalabrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the level or outcome of ibuprofen by influencing hepatic enzyme CYP2C9/ten metabolism. Minimal/Significance Unknown.Phenobarbital lowers the plasma levels of dicumarol (title Beforeh